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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Li Deng

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Open access Sep 2026

Glucose-induced histone lactylation confers metformin resistance in colorectal cancer stem cells

Cancer stem cells (CSCs) can adapt their metabolism, which limits the effectiveness of therapies targeting metabolic pathways. Here we show that high glucose conditions promote metformin resistance in CD133⁺ colorectal CSCs by driving a switch from glucose dependence to lipid use. Mechanistically, metformin increases...

Xiangrui Li, Li Deng, Tian-Ge Zhang et al. · 0 citations

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