BACKGROUND
Localized biofilm-associated infections such as chronic wounds, osteomyelitis, and implant infections remain difficult to treat with systemic antibiotics amid rising resistance. Hydrogel delivery may enhance bacteriophage (phage) therapy by protecting phages, prolonging residence, and enabling controlled rel...
N. Walter, Christoph Brochhausen, T. El Khassawna et al.· Journal of Controlled Releas...· 0 citations
We identified and characterized a novel lytic phage, HMGUpa1, which exhibited distinct infection efficiency across five characterized P. aeruginosa clinical isolates. While all strains were susceptible to the phage, killing efficacy varied significantly, with strain 50071 showing the highest sensitivity. To explore the...
C. Winkler, Wanqi Huang, Torben Sanders et al.· Scientific Reports· 0 citations
A hybrid model in which LLMs generate draft patient information that is subsequently refined by clinical experts is presented, particularly in rapidly evolving therapeutic domains lacking standardized educational resources, to address antimicrobial resistance.
N. Walter, D. Amanatullah, L. Debarbieux et al.· npj Viruses· 0 citations
Analysis of strain-specific transcriptomic and metabolic responses of Clostridium butyricum and Bacteroides thetaiotaomicron grown in pure anaerobic culture with 0.1% MSG suggested that MSG's physiological effects may depend on which bacterial groups dominate an individual’s microbiome.
