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Author

Lifeng Yang

2 papers indexed here

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Oct 2026

MetaTag: A Biochemical Reaction-Guided Design Strategy for New Metabolite Discovery.

Most small-molecule features detected in untargeted metabolomics remain unannotated, representing the dark matter of the metabolome. Here, we introduce MetaTag, a biochemical-reaction-guided framework that generates high-probability novel metabolites by combining abundant endogenous metabolites with common enzymatic tr...

Cong Li, Q. Xu, Li-Ying Zhang et al. · 0 citations
Aug 2026

Hepatocyte hnRNPK preserves mitochondrial integrity to restrain liver injury and fibrosis.

The findings establish the loss of hnRNPK as a central, unifying mechanism in liver fibrogenesis by governing the Opa1 splicing axis and targeting this RNA-mitochondria axis represents a potent, etiology-independent therapeutic strategy for chronic liver disease.

Qian Peng, Sujuan Wang, Yu-Feng Zhang et al. · 0 citations

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