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Review Open access Oct 2026

Autophagy as a potential link between progesterone responsiveness and endometrial immune function in recurrent implantation failure

Recurrent implantation failure (RIF) describes a clinical outcome rather than a single diagnosis or immune disorder. During progesterone-driven decidualization, changes in stromal metabolism and epithelial secretion accompany the production of signals that support uterine natural killer (uNK) cell residency. Autophagy...

Li Guo, Jing-Hong Xie, Mengyu Wang et al. · 0 citations
Oct 2026

Integrative single-cell transcriptomics and experimental validation reveal that Tusizi Formula ameliorates premature ovarian insufficiency by preserving the primordial follicle pool and promoting granulosa cell differentiation.

BACKGROUND Premature ovarian insufficiency (POI) is characterized by reduced ovarian reserve and disrupted folliculogenesis, often driven by granulosa cell (GC) dysfunction. Traditional Chinese medicine formula TSZF has been widely used for POI, yet its mechanisms and active components remain unclear. This study aimed...

Si-Qi Li, Yuan Li, Jian-Ying Kang et al. · 0 citations

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