Li-Hong Chen

Berberine as a multitarget modulator of metabolic inflammation: molecular mechanisms, circadian regulation, and translational perspectives

Metabolic inflammation is a chronic, low-grade inflammatory state sustained by metabolic stress, organelle dysfunction, immune activation, and gut-derived signals. Because these processes are closely interconnected, single-target interventions may be insufficient. Berberine, a plant-derived isoquinoline alkaloid, has a...