Author

Li-Hua Yang

2 papers indexed here

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Open access Sep 2026

11-Oxo-mogroside V attenuates lung adenocarcinoma progression by disrupting metabolic homeostasis and suppressing TGFβ2/Myc-dependent oncogenic signaling

Highlights • 11-oxo-mogroside V suppresses LUAD progression in vitro and in vivo.• It disrupts metabolic homeostasis by reducing ATP, glucose, and LDH.• The compound induces G0/G1 arrest and promotes apoptosis in cancer cells.• It directly targets TGFβ2, HDAC1, and c-Myc to block oncogenic signaling.• Multi-pathway int...

Xin-Yu Chen, Li-Hua Yang, Jiao Li et al. · Translational Oncology · 0 citations

Open access Aug 2026

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

This study identified GPATCH4, CCT3, C19orf53, UACA, PPM1M, and LIN37 as key genes mediating TKI resistance in HCC, and identified Ferroptosis, epithelial‐mesenchymal transition and hypoxia were new research directions, which were closely related to the pathways investigated in this study.

Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al. · Cancer Medicine · 0 citations