Dysregulated JAK2 signaling delays fracture healing by enhancing STAT3/NF-κB signaling and inhibiting BMP2-mediated osteogenesis.
These findings identify bidirectional JAK2 dysregulation as a potential mechanism linking metabolic dysfunction and sustained JAK2 activation to impaired bone regeneration andModulation of JAK2-mediated inflammatory signaling may represent a potential therapeutic approach to improve fracture repair in metabolic and hem...