Li-Juan Song

Mechanism of Piper longum L. in the Treatment of Cerebral Ischemic Stroke Based on Network Pharmacology and Molecular Dynamics Simulation, With Verification by Surface Plasmon Resonance

Objective: To investigate the potential mechanisms of Piper longum L. in the treatment of cerebral ischemic stroke (CIS) and conduct experimental verification. Methods: Network pharmacology was used to identify intersecting targets of Piper longum L. and CIS. A drug-active component-target-disease network and the targe...

Prospects for treatment of cerebral ischemic stroke with Hydroxysafflower Yellow A.

Cerebral ischemic stroke (CIS) is characterized by high morbidity, disability, and mortality, representing a major global public health challenge and imposing a substantial social and economic burden worldwide. Cerebral ischemia/reperfusion (I/R) triggers complex pathological cascades, resulting in secondary brain inju...

Phenotypic shift of astrocytes from A1 to A2 induced by fasudil improves demyelination recovery in cuprizone-treated mice