Open access
Sep 2026
Targeting TREM2+ and TIMD4+ Macrophages Reprograms the Tumor Microenvironment and Enhances PD-1 Blockade Efficacy in Intrahepatic Cholangiocarcinoma
TREM2+ and TIMD4+ macrophages are key regulators of the immunosuppressive TME in ICC, and combining anti-Trem2 and anti-Timd4 with anti-Pd-1 antibodies significantly improved treatment outcomes in the ICC mice.
Yao Li, Hong-Wen Liu, Lei Xu et al.
· Cancer Communications · 0 citations