Open access
Sep 2026
Repurposing Pimozide as a Geroprotector: Lifespan Extension via SKN-1 Activation and Collagen Remodeling in Caenorhabditis elegans
Aging is a major risk factor for chronic diseases, driving an urgent need for effective geroprotectors. Repurposing psychotropic agents offers an efficient strategy to accelerate anti-aging therapeutics development. In this study, we investigated the effects of pimozide (a diphenylbutylpiperidine-class antipsychotic) o...
Yu-Hong Huang, Mei-Jing Wang, Yi-Ming Zhou et al.
· Antioxidants · 0 citations