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Author

Li Ruan

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Open access Sep 2026

Injectable Fiber-Hydrogel Hybrid Scaffolds for Localized Growth Factor Delivery and Modulation of Vascular and Neuronal Cell Responses

Ischemic stroke is a leading cause of mortality and long-term disability worldwide and is characterized by neuronal loss, vascular impairment, and limited endogenous repair. Recovery after ischemic injury requires coordinated vascular and neural responses. However, the unfavorable post-stroke microenvironment, rapid lo...

Kai-Qin Mo, Li Ruan, Wen-Zhe Du et al. · 0 citations
Review Open access Jul 2026

Hydrogel coatings for titanium implants: From smart stimuli-responsive strategies to multimodal bone regeneration

This review summarizes the classification, fabrication methods, stimuli-responsive features, and emerging bone-regenerative applications of hydrogel coatings on titanium implants and discusses the prospects and challenges of functionalized hydrogel coatings for titanium implants in clinical translation.

Aoao Wang, Zebin Gui, Li Ruan et al. · 0 citations
Open access Jul 2026

A pleiotropic single-molecule, sustained-release regenerative scaffold enables coordinated repair after ischemic stroke

These results demonstrate that coupling a structurally engineered scaffold with a small molecule supports multiple repair-associated responses following ischemic stroke and offers a translational strategy for repairing ischemic brain injury.

Li Ruan, Wenzhe Du, Huaqi Wang et al. · 0 citations

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