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Li-Sha Lu

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Open access Sep 2026

Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation

Background Microplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear. Methods We integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based functional association...

Li-Sha Lu, Yuan-Ming Yang, Shun-Yong He et al. · 0 citations
Oct 2026

Study of the Mechanism of Xianglian Anchang Decoction Ameliorating Ulcerative Colitis Based on Transcriptomics and Network Pharmacology Analysis.

INTRODUCTION The therapeutic efficacy of Xianglian Anchang Decoction (XLAC) in Ulcerative Colitis (UC) has been established, but the underlying pharmacological mechanisms have remained poorly elucidated. In this study, we employed an integrated strategy combining network pharmacology, transcriptomic profiling, and in v...

Tian-Yu Gao, Cui-Mei Zhao, Li-Sha Lu et al. · 0 citations

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