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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Li Shen

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#diffusion models Review Open access Oct 2026

Estrogen and Alzheimer’s Disease: Neurobiology, Epigenetics, and AI-Driven Therapeutic Design

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and women are disproportionately affected. This review examines the evidence that estrogen signaling contributes to this disparity and asks what a molecularly targeted therapeutic would require. We first distinguish prevalence from incidence in the g...

Tian-Hua Zhai, Risa Garg, Pei-Ming Li et al. · 0 citations
Preprint Aug 2026

Auditable CT Phenotyping Through Report-derived Radiological Observations

Medical image foundation models can predict clinical phenotypes from computed tomography (CT), but strong performance leaves open whether they read disease-specific findings or shortcuts that correlate with the diagnosis. We tested this in 221 electronic-health-record (EHR) phenotypes using Auditable CT phenotyping (AC...

Riga Wu, W. Witschey, Yi-Cheng Li et al. · 0 citations
Open access Jul 2026

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer’s disease lipid-processing microglia

Together, these results advance a described disease-associated microglial state into a reproducible, mechanistically framed regulatory model, providing candidate regulators, upstream ligands, and pharmacological probes for functional validation.

C. Zheng, Tianhua Zhai, Fang-Yuan Zhang et al. · 0 citations

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