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Author

Lisheng Wang

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Open access Oct 2026

Design, Synthesis, and Antibacterial Activity of Citral Derivatives Containing Schiff Base Structures

The growing threat posed by antimicrobial resistance is making current therapies increasingly ineffective, underscoring the urgent need for novel antimicrobial agents. To address this challenge, a series of novel Schiff base‐containing citral derivatives were synthesized through structural modification of citral. T...

Jun-Wei Xie, Ge-Yin Zhang, Hong-Bin Si et al. · 0 citations
Aug 2026

Discovery and characterization of a sophoridine-derived TNIK inhibitor with antitumor activity in hepatocellular carcinoma.

This work identifies YM17 as a potent sophoridine-derived TNIK inhibitor with cellular target engagement and in vivo anti-HCC activity and highlights the value of integrating phenotype-guided natural product scaffold diversification with proteome-scale target deconvolution for anticancer lead discovery.

Yong-Quan Wei, Zi-Yi Wang, Die Sun et al. · 0 citations

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