Ultrasound-Triggered HSC Membrane-Cloaked Nanotherapeutics Attenuate Liver Fibrosis via Simultaneous Modulation of Mitophagic Flux and the TGF-β/Smad3 Cascade.
This study presents an ultrasound-triggered therapeutic platform based on melatonin-loaded and perfluoropentane-encapsulated mesoporous silica nanoparticles, which are further cloaked with activated hepatic stellate cell membranes (HM-Mel@PFP-MSNs), designed for the precision treatment of liver fibrosis. This innovativ...