Integrated network toxicology and multiomics analyses reveal the mechanisms underlying trimethyltin chloride-induced epilepsy and the ameliorative effects of astaxanthin via NFKB1 and IL6.
Trimethyltin chloride (TMT) is a ubiquitous neurotoxic organotin pollutant that induces epilepsy, while the natural marine product astaxanthin (AST) exerts potent antioxidant, anti-inflammatory and neuroprotective effects. However, the causal molecular mechanisms of TMT-induced epilepsy and the targeted intervention me...