Epidermal growth factor receptor activation is associated with NSCLC cells resistance to ferroptosis and correlates with ROS-NRF2-GCLC/GCLM pathway activation.
Mutations of epidermal growth factor receptor (EGFR) closely correlate with differential ferroptosis sensitivity in select cell lines, but the underlying mechanism is poorly understood. In this study, we identified the epidermal growth factor (EGF)-activated EGFR as a correlate of ferroptosis suppression in non-small c...