Forsythoside E alleviates chronic unpredictable mild stress-induced depressive-like behaviors in mice: associations with blood-brain barrier integrity and neuroinflammatory changes in the prefrontal cortex.
FE markedly attenuated CUMS-induced behavioral abnormalities, including reduced sucrose preference, prolonged feeding latency, increased immobility, and diminished central exploration, though body weight loss was not significantly corrected, and suggest a potential involvement of neurovascular and inflammatory processe...