Author

Li-Wei Zhang

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Open access Sep 2026

Epigenetic training licenses naïve CD8+ T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8+ T cells for future activation. H2A.Z deficiency disrupts naïve T cell homeostasis...

Meng-Jie Lv, Ji-Yu Ding, Hai-Zhen Long et al. · Science Advances · 0 citations

Open access Aug 2026

Single-cell profiling of mitochondrial phenotyping-coupled mtDNA genotyping.

Simultaneously profiling mitochondrial DNA (mtDNA) heteroplasmy and phenotypic variability at the single-cell level remains a challenge due to the absence of integrated methods that map mitochondrial genotypes alongside their functional states. We introduce human single-cell mitochondrial phenotype-coupled mtDNA sequen...

Zheng-Yang Zhang, Li-Wei Zhang, Peng An et al. · Proceedings of the National... · 0 citations