Li-Wen Bai

Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

Tyrosine-selective peptide modification provides a valuable route to late-stage diversification, yet current methods remain largely limited to site-specific labeling and rarely extend to macrocyclization or ligand discovery within a unified platform. Here, we report a tyrosinase-catalyzed tyrosine–aniline coupling pl...