Abstract Depletion of cellular NAD+ is an increasingly recognized bacterial antiphage strategy, and many phages counter this pressure by rebuilding NAD+ from its cleavage products. In the NARP1 pathway, Adps converts ADP-ribose (ADPR) and ATP into ADPR-PP, the immediate substrate for Namat-dependent NAD+ synthesis, but...
Astragalus membranaceus polysaccharides (APS), bioactive macromolecules derived from the roots of Astragalus membranaceus (Fisch.) Bge., exert immunomodulatory, anti-inflammatory, antioxidant, and metabolic regulatory effects. However, the molecular features and compositional profiles of APS are strongly influenced by...
Jing Cheng, Qian-Hui Liu, Rui Zhu et al.· International Journal of Bio...· 0 citations
The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.
X. Pang, Yuxin Gan, Qing-Yuan Hu et al.· Bioorganic chemistry (Print)· 0 citations
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