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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Li-Xuan Zhu

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Open access Sep 2026

Disruption of CTCF-mediated IGF2 repression promotes AKT-dependent mitochondrial oxidative stress and chondrocyte senescence in osteoarthritis.

AIMS The upstream epigenetic mechanisms linking chronic inflammation to mitochondrial dysregulation and chondrocyte senescence in osteoarthritis (OA) remain incompletely defined. This study investigated whether inflammation-associated loss of CTCF occupancy at the IGF2-H19 intergenic region contributes to IGF2 upregula...

Chun-Pan Zhang, Fei Xu, Jiang-Ping Wu et al. · 0 citations

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