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Author

Li-Ya Lin

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Review Open access Oct 2026

The apelin/APJ system as a complementary target to RAAS blockade in cardiorenal disease.

BACKGROUND Cardiorenal disease emerges from reciprocal injury among the heart, vasculature, kidney, and metabolic organs, with maladaptive neurohormonal activation as a central pathobiological driver. Although renin-angiotensin-aldosterone system (RAAS) blockade has transformed cardiorenal care, substantial residual ri...

Li-Ya Lin, Han-Xiao Yu, Min-Yue Jia et al. · 0 citations
Open access Jul 2026

IFIT1+ Tumor-Associated Macrophages Suppress Cancer Stemness and Enhance Chemosensitivity via the TNFSF10-TNFRSF10B Axis in Epithelial Ovarian Cancer.

These insights shed light on the functional diversity of macrophages, highlighting that driving tumor-associated macrophages toward a sustained, interferon-primed IFIT1+ phenotype represents a promising therapeutic approach to target cancer stem cell populations in epithelial ovarian cancer.

Rui Liu, Yi-Lin Fang, Ru-Xin Zheng et al. · 0 citations

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