OBJECTIVES
Lenacapavir, a first-in-class, long-acting capsid inhibitor (CAI), has been approved for HIV-1 treatment and prevention. However, naturally occurring resistance to the HIV-1 CAI at the quasi-species level is rarely reported.
METHODS
Using next-generation sequencing (NGS), we obtained 495 HIV-1 near-full-le...
Pei-Jiang Pan, Cai-Chang Mo, Rong-Feng Chen et al.· Journal of Antimicrobial Che...· 0 citations
Gut microbial dysbiosis contributes to alcoholic liver disease (ALD), but the pathogenic bacteria and mechanisms remain unclear. We investigated the role of Streptococcus salivarius (S. salivarius) in ALD mice using a modified 12-week NIAAA chronic-plus-binge ethanol regimen with oral gavage. S. salivarius aggravated h...
Based on the combined phylogenetic, chemotaxonomic, and phenotypic evidence, the two strains could be classified as a novel species within the genus Leucobacter, for which the name Leucobacter faecis sp.
Yu-Yuan Huang, Jing Yang, Qinglian Qin et al.· Current Microbiology· 0 citations
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