Open access
Nov 2026
Early Increases in GDF-15 Are Associated With Declines in Cardiac Function With Breast Cancer Therapy.
BACKGROUND Growth differentiation factor (GDF)-15 is a stress-responsive cytokine induced by mitochondrial dysfunction and genotoxic stress, mechanisms central to anthracycline cardiotoxicity. Whether early changes in GDF-15 following cancer therapy relate to subsequent cardiac dysfunction is not established. OBJECTI...
N. Wilcox, Cong-Ying Xia, Wei Yang et al.
· JACC: Advances · 0 citations