Li-Yuan Guo

Synthesis of Aminoacyl-2-Cyanopyrrolidine Compounds and Their Inhibitory Effect on the DPP-4 Enzyme.

BACKGROUND Diabetes mellitus is a major global health concern. DPP-4 (dipeptidyl peptidase-4) inhibitors containing a 2-cyanopyrrolidine scaffold are in clinical use; however, systematic evaluation of amides derived from amino acids adjacent to the N-2 position of GLP-1 (glucagon-like peptide-1) has not been reported....