Down-regulation of RhoA inhibits YAP by activating Hippo signaling to promote macrophage M1 polarization and enhance its phagocytosis, thereby inhibiting AML progression in preclinical models.
BACKGROUND Acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system. RhoA has been implicated in AML progression, but its role in regulating macrophage polarization and phagocytic function in the AML microenvironment remains unclear. METHODS RhoA expression level in AML tissues was analyzed by GE...