Open access
Aug 2026
HNF4α promotes urate excretion by activating ABCG2 and mediates the anti-hyperuricemic effect of saffron floral bio-residue.
BACKGROUND Current pharmacotherapies for hyperuricemia (HUA) are limited by variable efficacy and adverse effects, highlighting the urgent need for novel therapeutic targets and agents. The natural product saffron floral bio-residue (SFB) has demonstrated anti-hyperuricemic potential, but the underlying molecular mecha...
Na Chen, Jun Xiang, Jiaqi Li et al.
· Phytomedicine · 0 citations