Li-Zhen Piao

Emerging molecular mechanisms of the ECM–exosome growth-plate axis in idiopathic short stature

Idiopathic short stature (ISS) remains a clinically heterogeneous diagnosis in which impaired linear growth is often defined by exclusion rather than by mechanism. Increasing evidence suggests that ISS and related short-stature phenotypes may converge on overlapping growth-plate abnormalities characterised by disrupted...