Li-Zhou Song

Neutrophil plasticity in inflammation resolution: mechanisms and therapeutic potential

Programmed cell death in inflammation: interactions and holistic perspective

Programmed cell death (PCD) is a major regulatory mechanism that maintains tissue homeostasis and immune balance and strongly influences the initiation, progression and resolution of inflammation. Although apoptosis, pyroptosis, necroptosis and ferroptosis are individual PCD modes that are regulated by different molecu...

Integrated Mechanisms of the Gut-X Axis and Multi-Organ Injury in Sepsis.

Sepsis is a life-threatening syndrome defined by infection-triggered dysregulation of the host response, and its persistently high mortality and marked clinical heterogeneity remain major barriers to early risk stratification and individualized management. While the gut is increasingly recognized as a key modulator of...

Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy

This paper systematically discusses the potential application value of ferroptosis-related protein PTM in overcoming tumor immune escape, enhancing the antitumor activity of T cells and natural killer cells, and improving the clinical efficacy of immune checkpoint inhibitors (ICIs).

The interplay between chronic inflammation and tumorigenesis: unraveling the inflammation-driven axis.

Inflammatory biomarkers and epigenetic inflammation scores may support cancer risk stratification, early detection, prognostic assessment and treatment monitoring; however, most should be interpreted as complementary laboratory tools rather than stand-alone diagnostic tests, and clinical implementation requires standar...

The cGAS-STING pathway: mechanistic basis, dual biological functions and translational therapeutic advances

This review systematically investigates the distinct functional states and biological behaviors of the cGAS-STING pathway under a variety of disease conditions to provide comprehensive theoretical references and research directions for follow-up basic mechanistic studies and clinical transformation of cGAS-STING target...

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.