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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Lía Jove

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Open access Sep 2026

Development of a 3D-bioprinted tumour-on-chip with tunable hydrogel properties for monitoring colorectal cancer cell migration and invasion

Understanding the mechanisms governing cancer cell migration is essential for elucidating the early events of colorectal cancer metastasis. Here, we report the development of a light-tunable three-dimensional (3D) bioprinted tumour-on-chip platform for monitoring the migration of colorectal cancer cells under biomimeti...

Adrian García, Lía Jove, M. Pereira et al. · 0 citations
Open access Jul 2026

E3 ubiquitin-ligase Hakai regulates LRP4 stability and Wnt/β-catenin signalling in colorectal cancer cells

Mechanistically, the findings support that Hakai regulates LRP4 stability, a negative regulator of Wnt signaling, consistent with ubiquitin-dependent mechanism, and highlight Hakai inhibition as a potential CSC-directed therapeutic strategy in colorectal cancer.

Andrea Rodríguez-Alonso, Lía Jove, G. Alfonsín et al. · 0 citations

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