Lian-Yue Guan

A Guide to autophagy-dependent cell death: concepts, criteria, and mechanisms.

Macroautophagy (hereafter referred to as autophagy) is generally regarded as a cytoprotective process that maintains cellular homeostasis through intracellular recycling and metabolic adaptation. However, under certain conditions, autophagic machinery can contribute directly to cell death. Defining when autophagy funct...