Author

Liang Chen

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Open access Aug 2026

High prevalence of KPC-3 in carbapenem-resistant Pseudomonas aeruginosa across multiple clonal lineages in China

Background The epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa is rapidly evolving in China. While blaKPC-2 remains the predominant KPC variant in P. aeruginosa, blaKPC-3 has rarely been documented in this pathogen. This study investigated the molecular epidemiology, resistanc...

Shan-Shan Wang, Mei-Lan Li, Zhixuan Chen et al. · bioRxiv · 0 citations

Open access Aug 2026

RpoE-mediated virulence attenuation elicits protective immunity in hypervirulent Klebsiella pneumoniae

ABSTRACT The global emergence of hypervirulent Klebsiella pneumoniae (hvKP) and extensively drug-resistant (XDR) phenotypes has precipitated a severe public health crisis with limited therapeutic options. In particular, the hypervirulent ST65 and ST23 lineages, alongside the carbapenem-resistant ST11 lineage, have been...

Yaxuan Zhai, Qiyuan Jin, Jia-Wen Shi et al. · Emerging Microbes and Infect... · 1 citation

Open access Aug 2026

Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype

ABSTRACT Hypermutation-driven evolution is a major contributor to antibiotic resistance in some bacterial pathogens, but its role in Klebsiella pneumoniae remains poorly defined. We analyzed 11 KPC-producing ST258 K. pneumoniae isolates collected serially over ~4 years from a host with persistent colonization and recur...

Shao-Ji Cheng, Cornelius J. Clancy, G. Fleres et al. · Antimicrobial Agents and Che... · 0 citations