Author

Liang Kang

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Open access Aug 2026

Single-cell and spatial transcriptomics characterisation of RSPO2+ nucleus pulposus cells reveals a WNT/FN1–CD44 degenerative axis and therapeutic targets in IVDD

Background Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, imposing a significant economic and physiological burden on individuals and society worldwide. Although dysregulation of the WNT/β-catenin pathway is considered an important factor contributing to the dysfunction of nucleus p...

Qiu-Wei Li, Guoyan Liang, Kaida Bo et al. · Journal of Orthopaedic Trans... · 0 citations

Open access Jul 2026

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

BACKGROUND Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) death and hinders self repair. Mesencephalic astrocyte-derived neurotrophic facto...

Chen-Hao Zhao, Liang Kang, Jiaqi Wang et al. · Cell Biology and Toxicology · 0 citations

Open access Jul 2026

Hounsfield unit measurements from different regions of interest in lumbar spine CT: correlation with DEXA-derived bone mineral density and fracture status.

Different lumbar CT ROI methods demonstrated comparable performance in assessing BMD and discriminating thoracolumbar fragility fracture status, and sensitivity analysis confirmed that exclusion of substituted vertebral levels did not materially affect the results.

Zengkai Zhou, Jia-Qi Wang, Lu-Ping Zhou et al. · BMC Musculoskeletal Disorder... · 0 citations