Oct 2026
LC-MS/MS method for quantification of dupilumab in human serum using Protein G enrichment.
Dupilumab, a monoclonal antibody targeting IL-4Rα, is used for the treatment of type 2 inflammatory diseases. Recent studies have revealed a nonlinear relationship between its serum concentration and clinical response, particularly a "biological tipping point" during dose interval prolongation, highlighting the need fo...
Kun-Peng Yang, Jian-Hua Wu, Cheng-Ming Yang et al.
· Journal of Pharmaceutical an... · 0 citations