Author

Liang-Ming Li

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Review Aug 2026

One ligand, multiple fates: the multi-receptor signaling network of FSTL1 and receptor-selective intervention strategies.

Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein involved in cardiovascular protection, tissue repair, inflammation, fibrosis, and tumor biology. Accumulating evidence indicates that FSTL1 exerts opposing effects across tissues and disease contexts, producing either protective or pathogenic outcomes. Altho...

Yu Hou, C. Fang, Wen-Qi Yang et al. · Biochemical Pharmacology · 0 citations

Review Open access Sep 2026

GPR75: A Dual-Ligand Receptor for 20-HETE and CCL5 with Emerging Roles in Central and Peripheral Regulation of Metabolic Diseases.

G protein-coupled receptor 75 (GPR75) has recently attracted considerable attention as a novel regulator of metabolic, immune, and vascular processes. Current evidence suggests that two structurally distinct molecules have been proposed as candidate endogenous ligands for GPR75: 20-hydroxyeicosatetraenoic acid (20-HETE...

Yu Hou, Shu-Jing Liu, Liang-Ming Li · Pharmacological Research · 0 citations