Jul 2026
Novel Selenium-Containing Small Molecule PD-L1 Inhibitors: Design, Synthesis, and Evaluation of the Antitumor Activity.
Cell-based assays showed that SA13 can mediate the internalization of PD-L1 and strongly block hPD-1 and hPD-L1 interaction, demonstrating its effectiveness in biological events and indicating that SA13 is a promising and safe novel antitumor agent worthy of further development.
Jianwei Wang, Shenwei Yu, Liang Qian et al.
· Journal of Medicinal Chemist... · 0 citations