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Review Open access Jul 2026

Hidden proteins encoded by non-canonical open reading frames: A review.

A concise summary of the origin, discovery methods, and classification of non-canonical ORFs offers insights into the origins and functions of non-canonical ORF-encoded peptides from an evolutionary perspective, while also exploring the biological functions and regulatory mechanisms of these non-canonical ORF-encoded hidden proteins in tumorigenesis and progression.

Jiang-Xue Li, Yanxia Qin, Zhao Li et al. · 0 citations

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