Tertiary Lymphoid Structures in Hepatocellular Carcinoma: Prognostic Biomarker, Immunotherapy Predictor, and Emerging Therapeutic Target.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with many patients presenting with advanced disease that does not respond to standard treatments. While immune checkpoint inhibitors (ICIs) have improved outcomes, their effectiveness is limited in immunologically "cold" tumors...