Perampanel improves cognitive function in epilepsy by targeting AMPA receptor subunit GluR2-mediated endoplasmic reticulum stress and synaptic plasticity.
AIMS This study aimed to explore the action mechanism of Perampanel (PER) in epilepsy treatment, particularly the associations with endoplasmic reticulum stress (ERS). METHODS Epilepsy mice model was induced by injecting kainic acid (KA) into hippocampus of mice, and KA-stimulated hippocampal neurons were used as in...