The mechanism of SOX4/IGF2BP3/TRIB3 axis inhibiting autophagy and aggravating liver injury in sepsis.
Sepsis-associated liver injury (SALI) is a serious complication with limited treatment options. While protective autophagy is often suppressed in sepsis, the underlying mechanisms remain unclear. This study investigated whether the SOX4/IGF2BP3/TRIB3 pathway contributes to liver dysfunction by suppressing cytoprotectiv...