Author

Li-Hua Ding

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Sep 2026

CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget detection,...

Hao-Yu Shen, Xin-Yuan Pan, Yan Wu et al. · Analytical Chemistry · 0 citations

Open access Aug 2026

Orthogonal Cas13a/Cas12a cascade for one-pot amplification-free detection of miRNA-21.

This one-pot Cas13a/Cas12a cascade fluorescence biosensor enabled quantitative detection of miRNA-21 over a concentration range of 1-1000 pmol/L within 60 min, with a low detection limit of 0.66 pM.

Jing Yuan, Meng Shen, Li-Hua Ding et al. · Talanta: The International J... · 0 citations

Review Jul 2026

Integrating CRISPR/Cas Biosensors with Advanced Platforms: A Holistic Path Toward Preamplification-free, Multiplexed, and Continuous Molecular Monitoring.

This review discusses how nanomaterials facilitate signal generation and transduction, how microfluidics automates, multiplexes, and miniaturizes "all-in-one" devices, and how orthogonal CRISPR systems can enable robust multiplexing.

C. Effah, Xinyu Li, Qi-Meng Zhang et al. · ACS Sensors · 1 citation