Fto-mediated m6A demsupplementethylation of SNHG9 Enhances PINK1-Dependent mitophagy and reverses cisplatin resistance via nuclear EZH2 ubiquitination.
Cisplatin (CDDP) resistance in lung adenocarcinoma (LUAD) is associated with increased N6-methyladenosine (m6A) RNA modification. Although proteolysis-targeting chimeras (PROTACs) that recruit E3 ligases have shown therapeutic potential, the role of nuclear ubiquitination in CDDP resistance remains unclear. Here, m6A-e...