Open access
Aug 2026
Active ingredients and molecular targets of Tripterygium wilfordii against colorectal cancer: network pharmacology, molecular docking, molecular dynamics simulations and in vitro evaluation
Tryptophenolide (Lei4) showed moderate but reproducible anti-CRC activity and directly inhibited EGFR kinase activity in vitro, supporting EGFR pathway inhibition as one mechanism contributing to its cellular effects.
Qian Gu, Shi-Lei Zhao, Xin Zhang et al.
· Journal of Computer-Aided Mo... · 0 citations