Hepatic ChREBP Drives Cardiac Remodeling via ApoM Non-transcriptional Repression
BACKGROUND: Pathological cardiac remodeling is a hallmark of numerous cardiovascular diseases and develops into heart failure. As a systemic disease, effective treatments for cardiac remodeling from a tissue crosstalk perspective are still significantly unmet. METHODS: Hepatocyte-specific ChREBP (carbohydrate response...