Open access
Aug 2026
Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming
The Hippo pathway components YAP and TAZ have been implicated in tumor immunity, but the role of upstream kinase LATS1 in colon cancer immune evasion remains unclear. This study aimed to investigate the function of LATS1 in regulating the tumor immune microenvironment (TME) of colon cancer. Human colon cancer tissues...
Zhe Zhang, Hankun Liu, Yuxuan Li et al.
· Scientific Reports · 0 citations