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Open access Aug 2026

HMGA2 is a highly sensitive marker for DICER1-related tumours.

AIMS DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1-related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent-onset tumours. One of these, pitu...

Paul S Thorner, Anne-Laure Chong, Naciba Benlimane et al. · 0 citations

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