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Sep 2026

Forsythiaside A suppresses PANoptosis to alleviate senecionine-induced hepatotoxicity.

ETHNOPHARMACOLOGICAL RELEVANCE Senecio scandens Buch.-Ham. ex D.Don (Qianliguang) is widely used in China, but its clinical application is limited due to the presence of pyrrolizidine alkaloids (PAs), which are well-known natural hepatotoxins. Forsythia suspensa (Thunb.) Vahl (Lianqiao), traditionally applied for heat-...

Yu Meng, Shu-Hui Li, Jia-Qi Yao et al. · 0 citations
Open access Jul 2026

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling

Oxidative stress and impaired mitochondrial homeostasis are critical drivers of drug-induced liver injury (DILI), both of which are negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1). In this study, a dual-action strategy was adapted to develop a novel KEAP1 degrader with high liver exposure for mitiga...

Yanyan Deng, Leizhi Xu, Xiaoting Niu et al. · 0 citations

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