Open access
Jul 2026
Cryoelectron tomography reveals an age-related decline in mitoribosomes that contributes to T cell dysfunction in older individuals.
Using cryoelectron tomography, the structure and spatial organization of mitochondrial ribosomes in primary human CD8+ T cells under physiological conditions are resolved and an age-related loss of mitoribosomes is revealed, contributing to mitochondrial dysfunction and the subsequent decline in T cell function observe...
Jing-Wen Chen, Li-Li Su, Bangze Pan et al.
· Proceedings of the National... · 1 citation