Adenoviral-Mediated SIRT1 Expression Restores Lung Architecture and Reduces Fibrotic Progression in Experimental Models.
Background: Pulmonary fibrosis (PF) involves remodeling of lung architecture and limited therapeutic options are available. Sirtuin 1 (SIRT1), an epigenetic regulator, has emerged as a promising antifibrotic target due to its role in apoptosis, inflammation, and chromatin remodeling. Methods: We evaluated the effects o...